Acyclovir lung penetration









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The example of the acyclovir experience. CL with and without proportional dependence on creatinine CL, V with and without proportional dependence on body weight, and V with or without interindividual variance. No special measures were taken to control food intake. The acyclovir concentrations in serum and CSF were also compared with those obtained for five MS patients after long-term valacyclovir treatment. The CSF acyclovir concentrations at 2 and 8 h were 2. MacDiarmaid-Gordon, A.

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Antibiotic Penetration Into Lung Tissues

The limit of quantification was 0. Although the serum acyclovir concentrations after oral administration of valacyclovir at 1, mg t. As an important part of that survey we performed an independent pharmacokinetic study in order to determine the concentration of acyclovir in cerebrospinal fluid CSF. National Center for Biotechnology Information , U. Blood samples were obtained before treatment and on day 7 for safety analysis. Acyclovir has previously been shown to enter the CSF in experimental animals as well as in humans. CNS and CSF acyclovir levels are also of interest when patients are evaluated for symptoms or signs of suspected neurotoxicity.

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Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanine in serum and urine using solid-phase extraction and high-performance liquid chromatography. An important observation, often overlooked, is that levels in CSF vary considerably less over time than levels in plasma. The acyclovir concentrations have been reported for only a small number of patients with neurotoxicity. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. The possible involvement of herpesviruses in the pathogenesis of multiple sclerosis MS was recently investigated in a clinical trial of valacyclovir in patients with MS.

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Description: Thus, we believe that our findings have a more general application for acyclovir and valacyclovir treatment. Author information Article notes Copyright and License information Disclaimer. Pharmacokinetics and distribution over the blood brain barrier of two acyclic guanosine analogs in rats, studied by microdialysis. An exponentially distributed error model was chosen. This does not necessarily imply that similar concentrations are found in the brain parenchyma. The possible involvement of herpesviruses in the pathogenesis of multiple sclerosis MS was recently investigated in a clinical trial of valacyclovir in patients with MS. Linear regression on the log concentration versus time was used to calculate the terminal elimination rate constant k el. Blood samples were obtained before treatment and on day 7 for safety analysis. Acute renal failure induced by oral acyclovir.
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